NCT06580977 Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease
| NCT ID | NCT06580977 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Heidelberg University |
| Condition | Parkinson Disease |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2024-02-27 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2024-02-27 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study aims to assess the effects of cardiovascular (aerobic) training on memory formation and cognitive function in people with Parkinson's disease. Participants will be randomly allocated to one of two groups either performing cardiovascular training (experimental group) or stretching (control group) for twelve weeks, three times a week. The primary aim is to examine whether moderate-intense cardiovascular training (MICT) improves procedural memory formation (primary outcome) compared to stretching. Secondary outcomes include episodic memory formation, cognitive function, cardiorespiratory fitness, sleep quality, and brain-derived neurotrophic factor (BDNF) blood concentration levels.
Eligibility Criteria
Inclusion Criteria: * Diagnosed Parkinson's disease * Disease stage ≤3 on the Hoehn \& Yahr scale * Age ranging from 50 - 80 years * Naive to the memory tasks (primary outcomes) * Ability to stand and walk at least 10 meters independently Exclusion Criteria: * Atypical Parkinsonism * Significant level of cognitive impairment (i.e., Montreal Cognitive Assessment \<21) * Deep brain stimulation or brain pacemaker * Diagnosed psychiatric illness * Known clinically relevant neurological, internal or orthopedic conditions besides Parkinsonism that would interfere with the exercise paradigm * Exceeding the recommended level of cardiovascular exercise for older adults (i.e., cardiovascular exercise done ≥150 min per week of moderate-intensity or ≥75 min per week of vigorous-intensity)
Contact & Investigator
Simon Steib, Prof. Dr.
PRINCIPAL INVESTIGATOR
Heidelberg University
Frequently Asked Questions
Who can join the NCT06580977 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 80 Years, studying Parkinson Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06580977 currently recruiting?
Yes, NCT06580977 is actively recruiting participants. Contact the research team at simon.steib@issw.uni-heidelberg.de for enrollment information.
Where is the NCT06580977 trial being conducted?
This trial is being conducted at Heidelberg, Germany.
Who is sponsoring the NCT06580977 clinical trial?
NCT06580977 is sponsored by Heidelberg University. The principal investigator is Simon Steib, Prof. Dr. at Heidelberg University. The trial plans to enroll 60 participants.
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