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Recruiting NCT05644457

NCT05644457 Exploratory Study of Early Biomarkers Allowing Dynamic Assessment of Response to Treatment in Cancers of the Head and Neck

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Clinical Trial Summary
NCT ID NCT05644457
Status Recruiting
Phase
Sponsor Royal Marsden NHS Foundation Trust
Condition Head and Neck Cancer
Study Type OBSERVATIONAL
Enrollment 50 participants
Start Date 2022-03-09
Primary Completion 2026-04

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL
Interventions
Circulating tumour DNA dynamics

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 50 participants in total. It began in 2022-03-09 with a primary completion date of 2026-04.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

DART is an exploratory molecular analysis study to assess potential early biomarkers of treatment response in squamous cell carcinoma of the head and neck (HNSCC)

Eligibility Criteria

Inclusion Criteria: * Age 18 years or older * Patients with histologically confirmed cancer of the head and neck with evidence of recurrent or locally advanced cancer not suitable for treatment with curative intent, or metastatic disease. * Receiving immunotherapy * Ability to give informed consent for biological sample collection. Exclusion Criteria: * Unable to undergo serial sample collection * Pregnancy

Contact & Investigator

Central Contact

Ben O'Leary

✉ ben.oleary@icr.ac.uk

📞 02071535337

Frequently Asked Questions

Who can join the NCT05644457 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Head and Neck Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT05644457 currently recruiting?

Yes, NCT05644457 is actively recruiting participants. Contact the research team at ben.oleary@icr.ac.uk for enrollment information.

Where is the NCT05644457 trial being conducted?

This trial is being conducted at London, United Kingdom.

Who is sponsoring the NCT05644457 clinical trial?

NCT05644457 is sponsored by Royal Marsden NHS Foundation Trust. The trial plans to enroll 50 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology