Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
Trial Parameters
Brief Summary
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times. Many studies find that this increases the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if there are interventions that might help to modify these disruptions is unknown. Project 2 (P2) of the CARRS center will test an innovative and mechanistic model of brain circuitry that uses multi-method approaches, takes a developmental perspective, and incorporates key sleep and reward constructs.
Eligibility Criteria
Inclusion Criteria: * Typically enrolled in a traditional high-school with synchronous learning (in-person or online synchronous learning, but not cyber- or home-schooling) \[school closures during the COVID-19 pandemic are an exception to this\] * Physically and psychiatrically healthy * Provision of written informed consent and assent * Additional inclusion criterion for Experimental protocol: Meets operational definition of late sleep timing (\>10:50PM habitual bedtime) Exclusion Criteria: * History of alcohol, cannabis, or illicit drug use in the past month, or greater than monthly use in the past year * Significant or unstable acute or chronic medical conditions * Frequent headaches or migraines * History of seizures * Current serious psychiatric disorder (e.g., depressive disorder, bipolar disorder, eating disorder, psychotic disorder diagnosis, alcohol use disorder or substance use disorder) that would interfere with completion of study procedures * Current syndromal sleep disor