NCT06297278 Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids

Trial Parameters

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Brief Summary

Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear. Recent research has provided new understanding of how fear is learned and can be regulated in the adolescent brain, and how the endocannabinoid system shapes these processes; however, these advances have not yet translated into improved therapeutic outcomes for adolescents with anxiety. This study will test whether a behavioral intervention, acute exercise, can help to improve fear regulation by enhancing brain activity and endocannabinoid signaling. This line of research may ultimately lead to more effect treatments for adolescent anxiety, and to new preventive strategies for at-risk youth.

Eligibility Criteria

Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and available for the duration of the study 3. 14-17 years of age upon enrollment 4. Right-handed 5. In good general health as evidenced by medical history 6. Adolescent and parent/guardian are English-speaking, as study assessments are in English 7. Availability of a parent or legal guardian who is willing to provide consent and attend all study visits Exclusion Criteria: 1. Traumatic brain injury with ongoing symptoms 2. Sensory (e.g., hearing) or physical (e.g., motor, balance) impairment or significant developmental delay 3. MRI participants: MRI contraindication (e.g., braces, implants, claustrophobia) 4. Any condition that would contraindicate blood draws (e.g., hemophilia, sickle cell) 5. Past or current diagnosis or presence of likely neurological disorder (e.g., epilepsy), psychotic disorder (e.g., schizophrenia, schizoaffective disorder), or bip

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