Trial Parameters
Brief Summary
There is increasing evidence that the usage and delivery of energy to the brain, known as brain energetics, is altered in people with Parkinson's disease (PD). This project will explore whether exercise has a positive impact on brain energetics using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) brain scanning in PD subjects. PD subjects will be scanned before and after a supervised exercise program to investigate the effect of exercise on brain energetics. In a separate study, the investigators will also scan healthy volunteers to compare brain energetics in the healthy brain with the brain energetics data in PD subjects acquired in this study.
Eligibility Criteria
Inclusion Criteria: 1. Idiopathic PD according to UK Brain Bank criteria (modified to permit inclusion of subjects with a family history) 2. Mild to moderate Parkinsonism (Hoehn \& Yahr stages I-III) 3. Currently exercise less than 120 minutes per week (PD non-exercisers) General exclusion criteria: 1. atypical Parkinson syndrome (progressive supranuclear palsy, multiple system atrophy, drug-induced etc.); 2. significant osteoporosis or arthritis; 3. history of cancer within 5 years of study participation; 4. high dose of radiation from other procedures within the year; 5. not able to tolerate being off PD medication for up to 24 hours; 6. a female subject who is breast-feeding or pregnant; 7. current or past substance use problems; 8. serious head injury with loss of consciousness for ≥ 5 minutes; 9. people with other chronic diseases such as diabetes, kidney problems, high blood pressure, other known neurological disorders, or heart diseases; 10. people who report having a significan