NCT06127342 Exercise and Emotional Learning in Posttraumatic Stress Disorder
| NCT ID | NCT06127342 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Christal L Badour |
| Condition | PTSD |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2024-05-13 |
| Primary Completion | 2026-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2024-05-13 with a primary completion date of 2026-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.
Eligibility Criteria
Inclusion Criteria: * Adults with PTSD related to interpersonal violence Exclusion Criteria: * Active or recent (within the last 3 months) severe substance use disorder(s) * Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes * Significant developmental disabilities * Current daily benzodiazepine or stimulant use with inability to abstain for study sessions * Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks) * Medical condition(s) that prohibit exercise * History of traumatic brain injury (TBI) with loss of consciousness \> 30 mins * Magnetic resonance imaging (MRI) contraindication(s) * Positive pregnancy test * History of seizure disorder * Spontaneous seizure(s) within the last 3 months
Contact & Investigator
Thomas G Adams, Jr., PhD
PRINCIPAL INVESTIGATOR
University of Kentucky
Frequently Asked Questions
Who can join the NCT06127342 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 64 Years, studying PTSD. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06127342 currently recruiting?
Yes, NCT06127342 is actively recruiting participants. Contact the research team at christal.badour@uky.edu for enrollment information.
Where is the NCT06127342 trial being conducted?
This trial is being conducted at Lexington, United States, Austin, United States.
Who is sponsoring the NCT06127342 clinical trial?
NCT06127342 is sponsored by Christal L Badour. The principal investigator is Thomas G Adams, Jr., PhD at University of Kentucky. The trial plans to enroll 100 participants.
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