NCT05934708 Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise
| NCT ID | NCT05934708 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Southern California |
| Condition | Inflammatory Response |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2025-03-07 |
| Primary Completion | 2026-05-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2025-03-07 with a primary completion date of 2026-05-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.
Eligibility Criteria
Inclusion Criteria: * 18-35 years of age * BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths \[15\] * Not taking contraception or other types of medication that could influence reproductive status * Regular menstruation * Non-pregnant * Medically free from chronic diseases * Novel to downhill running * Weight greater than or equal to 110 lbs * Not taking exogenous hormones * Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity Exclusion Criteria: * Amenorrhea or oligomenorrhea * Perimenopausal or menopausal * Recreational or professional trail or downhill runner * On a form of contraception * Cardiac disability * Pacemaker * Arterial disease * Uncontrolled hemorrhage * Blood clots * Pregnant or trying to become pregnant * Cancerous lesions * Sensory or mental impairment * Unstable fractures * Weight less than 110 lbs * Suffering from gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity * Taking exogenous hormones
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05934708 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 35 Years, studying Inflammatory Response. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05934708 currently recruiting?
Yes, NCT05934708 is actively recruiting participants. Contact the research team at eschroed@pt.usc.edu for enrollment information.
Where is the NCT05934708 trial being conducted?
This trial is being conducted at Los Angeles, United States.
Who is sponsoring the NCT05934708 clinical trial?
NCT05934708 is sponsored by University of Southern California. The trial plans to enroll 30 participants.