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Recruiting NCT04922762

Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 2

Trial Parameters

Condition Peripheral Vascular Diseases
Sponsor Virginia Commonwealth University
Study Type INTERVENTIONAL
Phase N/A
Enrollment 360
Sex ALL
Min Age 18 Years
Max Age 35 Years
Start Date 2021-12-06
Completion 2026-12
Interventions
Moderate Intensity, Normal Volume Exercise TrainingHigh Intensity, Normal Volume Exercise TrainingModerate Intensity, High Volume Exercise Training

Brief Summary

The purpose of this research study is to examine the effect of various forms of exercise training on blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).

Eligibility Criteria

Inclusion Criteria: * apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease * for PTSD group, a score of ≥ 33 on PCL-5 checklist * for GAD group, a score of ≥ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist * for Healthy Control group, a score of ≤ 10 on the GAD-7 self-report scale and \< 33 on the PCL-5 checklist Exclusion Criteria: * taking medications that could influence cardiovascular function * current smokers who have recently quit smoking * illicit drug use or excessive alcohol consumption * pregnant women * significant calorie restriction or vitamin/mineral deficiencies * limited English proficiency

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