Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
Trial Parameters
Brief Summary
This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the effects of cytisinicline on the neural substrates of cigarette cue reactivity.
Eligibility Criteria
Inclusion Criteria: 1. be between the ages of 18 and 65 and provide informed consent; 2. smoke 5 or more combustible cigarettes per day; 3. not seeking treatment for smoking; Exclusion Criteria: 1. current use of other smoking cessation aid (bupropion, varenicline, nortriptyline, NRT); 2. more than 3 months of smoking abstinence in past year; 3. use of non-cigarette tobacco product (pipe tobacco, cigars, smokeless tobacco, hookah) or electronic cigarettes more than 5 times in the 28-days prior to enrollment; 4. current use of psychoactive drug (excluding cannabis), as determined by urine toxicology; 5. current (past 12-month) DSM-5 diagnosis of substance use disorder for any substances other than tobacco and mild cannabis or mild-to-moderate alcohol use disorders; 6. lifetime history of psychotic disorders, bipolar disorders, or major depression with suicidal ideation; 7. current suicidal ideation or lifetime history of suicide attempt; 8. serious medical illness within past 3 months,