NCT07395401 Evaluation of Zinc Oxide Eugenol and Iodoform-Calcium Hydroxide as Filling Materials in Primary Molar Root Canals Prepared by Rotary and Manual Files
| NCT ID | NCT07395401 |
| Status | Recruiting |
| Phase | — |
| Sponsor | October University for Modern Sciences and Arts |
| Condition | Carious Primary Molars Indicated for Pulpectomy |
| Study Type | INTERVENTIONAL |
| Enrollment | 44 participants |
| Start Date | 2026-02-15 |
| Primary Completion | 2026-03-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 44 participants in total. It began in 2026-02-15 with a primary completion date of 2026-03-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized controlled clinical trial aims to compare the clinical and radiographic outcomes of Zinc Oxide Eugenol (ZOE) and Iodoform-Calcium Hydroxide (Metapex) as root canal filling materials in primary molars prepared using either rotary or manual instrumentation techniques. Forty-four teeth from children aged 5-8 years indicated for pulpectomy will be randomly allocated into four equal groups based on the combination of instrumentation method and filling material. Clinical parameters-pain, mobility, and sensitivity-will be assessed using standardized scales, while radiographic outcomes, including root resorption and bone density, will be evaluated using Cone Beam Computed Tomography (CBCT) at baseline, 6 months, and 12 months. The study seeks to determine which obturation material and canal preparation technique yield superior healing, adaptation, and resorption compatible with the physiological process of primary tooth exfoliation. Findings are expected to inform evidence-based selection of endodontic materials and instrumentation methods in pediatric dentistry.
Eligibility Criteria
Inclusion Criteria: 1. Apparently healthy cooperative children indicated for partial pulpectomy. 2. Restorable primary molars. 3. No mobility, or external pathological root resorption. Exclusion Criteria: 1. Uncooperative children. 2. Children with systemic medical illness. 3. More than 2/3 of root resorbed.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07395401 clinical trial?
This trial is open to participants of all sexes, aged 5 Years or older, up to 8 Years, studying Carious Primary Molars Indicated for Pulpectomy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07395401 currently recruiting?
Yes, NCT07395401 is actively recruiting participants. Contact the research team at nanis.nasser1@msa.edu.eg for enrollment information.
Where is the NCT07395401 trial being conducted?
This trial is being conducted at Giza, Egypt.
Who is sponsoring the NCT07395401 clinical trial?
NCT07395401 is sponsored by October University for Modern Sciences and Arts. The trial plans to enroll 44 participants.