NCT07666126 Evaluation of the Effect of Hyperuricemia on Alveolar Bone Loss
| NCT ID | NCT07666126 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Recep Tayyip Erdogan University Training and Research Hospital |
| Condition | Periodontal Diseases |
| Study Type | OBSERVATIONAL |
| Enrollment | 80 participants |
| Start Date | 2026-06-10 |
| Primary Completion | 2026-10-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 80 participants in total. It began in 2026-06-10 with a primary completion date of 2026-10-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Periodontitis is a multifactorial disease characterized by chronic inflammation of the gum tissue and alveolar bone destruction, and is known to be associated with various systemic diseases. Hyperuricemia, on the other hand, is a metabolic condition characterized by increased serum uric acid levels and can affect inflammation, oxidative stress, and bone metabolism. In recent years, the relationship between hyperuricemia and periodontal diseases has been increasingly investigated, but the biological mechanisms of this relationship have not yet been fully elucidated. Therefore, this study aimed to determine whether there is a relationship between hyperuricemia and periodontitis and to reveal the possible pathophysiological mechanisms of this relationship, which are shaped by inflammation, oxidative stress, and bone metabolism. A total of 80 individuals aged 18-65 years will be included in this clinical observational study. The periodontal status of the participants will be assessed using clinical periodontal parameters such as probing pocket depth, clinical attachment loss, plaque index, gingival index, and bleeding on probing. Participants will be divided into four groups according to their periodontal status and the presence of hyperuricemia: individuals with periodontitis and hyperuricemia, individuals with periodontally healthy and hyperuricemia, individuals with periodontitis but without hyperuricemia, and individuals with periodontally healthy and without hyperuricemia. Gingival crevicular fluid and serum samples will be taken from the participants. In these samples, receptor-mediated nuclear factor kappa B ligand, osteoprotegerin, total antioxidant status, total oxidant status, oxidative stress index, interleukin-1 beta, interleukin-10, interleukin-18, and nucleotide-binding oligomerization domain-like receptor protein 3 levels will be analyzed. This study is considered unique because it examines the relationship between hyperuricemia and periodontitis by evaluating inflammation, oxidative stress, and bone metabolism parameters together.
Eligibility Criteria
Inclusion Criteria: * Being between 18 and 65 years of age * Being systemically healthy or diagnosed with hyperuricemia * Having at least 20 natural teeth * Being periodontally healthy or diagnosed with periodontitis Exclusion Criteria: * Diabetes, cardiovascular disease, osteoporosis, chronic kidney disease, metabolic syndrome, and obesity are systemic diseases that may affect purine metabolism. * Smoking * Pregnancy or lactation * Having received periodontal treatment within the last 3-6 months * Use of antibiotics, anti-inflammatory drugs, or uric acid-lowering drugs * Presence of systemic diseases that may affect purine metabolism
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07666126 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Periodontal Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07666126 currently recruiting?
Yes, NCT07666126 is actively recruiting participants. Contact the research team at htcymnglu@hotmail.com for enrollment information.
Where is the NCT07666126 trial being conducted?
This trial is being conducted at Rize, Turkey (Türkiye).
Who is sponsoring the NCT07666126 clinical trial?
NCT07666126 is sponsored by Recep Tayyip Erdogan University Training and Research Hospital. The trial plans to enroll 80 participants.