NCT07448571 Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment
| NCT ID | NCT07448571 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Marmara University |
| Condition | Apical Periodontitis |
| Study Type | INTERVENTIONAL |
| Enrollment | 140 participants |
| Start Date | 2025-05-01 |
| Primary Completion | 2026-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 140 participants in total. It began in 2025-05-01 with a primary completion date of 2026-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment. The study includes adult patients who require non-surgical root canal retreatment due to persistent periapical lesions. The main questions it aims to answer are: Does regenerative endodontic treatment improve periapical healing compared with conventional non-surgical root canal retreatment? Does regenerative treatment increase long-term treatment success and tooth survival? Researchers will compare conventional non-surgical root canal retreatment with regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) to see if the regenerative approach results in better clinical and radiographic outcomes. Participants will: Be randomly assigned to receive either conventional retreatment or regenerative endodontic treatment. Undergo clinical and radiographic evaluations over a two-year follow-up period. Be assessed for pain, sensitivity, pulp vitality, hard tissue formation, and periapical healing.
Eligibility Criteria
Inclusion Criteria: * Patients aged between 18 and 50 years. * Single-rooted maxillary anterior teeth with closed apices. * Presence of periapical lesion confirmed radiographically. * Previously treated root canal tooth requiring non-surgical retreatment. * Tooth has not previously undergone non-surgical root canal retreatment. * Tooth is considered restorable. * Patient is systemically healthy. * Patient is willing to participate and provides informed consent. Exclusion Criteria: * Teeth without radiographic evidence of periapical lesion. * Teeth with developmental anomalies. * Patients with systemic diseases that may affect healing. * Pregnant patients. * Teeth presenting with internal or external root resorption.
Contact & Investigator
Idil OZDEN, PhD
STUDY CHAIR
Marmara University
Frequently Asked Questions
Who can join the NCT07448571 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Apical Periodontitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07448571 currently recruiting?
Yes, NCT07448571 is actively recruiting participants. Contact the research team at melikekaplanoglu37@gmail.com for enrollment information.
Where is the NCT07448571 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07448571 clinical trial?
NCT07448571 is sponsored by Marmara University. The principal investigator is Idil OZDEN, PhD at Marmara University. The trial plans to enroll 140 participants.