NCT07474571 Evaluation of Musculoskeletal Aging and Related Disorders Via Advanced Clinical Imaging
| NCT ID | NCT07474571 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Peking University People's Hospital |
| Condition | Osteoarthitis |
| Study Type | OBSERVATIONAL |
| Enrollment | 2,000 participants |
| Start Date | 2005-11-01 |
| Primary Completion | 2026-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 2,000 participants in total. It began in 2005-11-01 with a primary completion date of 2026-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Study Overview This clinical research focuses on the development and validation of a multimodal artificial intelligence (AI) platform designed for the automated diagnosis and precise staging of two major musculoskeletal conditions: Osteoporosis (OP) and Osteoarthritis (OA). By integrating diverse clinical imaging data, the study aims to provide a more objective and standardized approach to assessing bone and joint degeneration. Technological Core: Intelligent Staging Traditional diagnosis often relies on manual interpretation, which can lead to inter-observer variability. This study employs deep learning and multimodal imaging to: For Osteoporosis: Automatically quantify bone mineral density and micro-architectural changes to determine the stage of bone loss and evaluate fracture risk. For Osteoarthritis: Identify subtle radiological markers such as joint space narrowing and osteophyte formation to categorize the severity of joint degeneration according to international staging standards (e.g., Kellgren-Lawrence scale). Why This Matters Early Intervention: By identifying early-stage changes in bone density and joint integrity, clinicians can implement preventive treatments before significant disability occurs. Standardized Care: The intelligent diagnostic model provides a "digital second opinion," ensuring consistent staging across different healthcare settings. Efficiency: The automated workflow reduces the workload of radiologists while maintaining high diagnostic accuracy. Ethical Compliance The study is conducted at Peking University People's Hospital under the supervision of the Institutional Review Board (Approval No. 2026PHB097-001). It strictly adheres to international ethical standards, including the Declaration of Helsinki and Good Clinical Practice (GCP) guidelines, to ensure patient data privacy and safety.
Eligibility Criteria
Inclusion Criteria: * Age: Adults aged at least 18 years. * Gender: No gender restrictions; both male and female participants are eligible. * Imaging Data: Participants must have completed relevant clinical imaging scans of skeletal sites, including but not limited to X-ray, CT (plain scan), or MRI (plain scan). * Anatomical Integrity: The skeletal structure of the target area must be free from congenital or acquired deformities. * Absence of Implants: No internal fixation materials or orthopedic implants in the skeletal areas being assessed. Exclusion Criteria: * Pathological History: Patients with a history of prior pathological fractures. * Malignancy: Patients seeking treatment or diagnosed with bone tumors or other systemic malignancies. * Medication History: Patients with a history of long-term steroid use, which may significantly affect bone density and joint structure. * Recent Treatment: Patients who have undergone radiotherapy or chemotherapy within the past six months. * Data Quality: Patients whose imaging data is of insufficient quality for AI analysis or lacks clear clinical diagnostic "gold standard" references (e.g., missing DXA results for osteoporosis staging).
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07474571 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Osteoarthitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07474571 currently recruiting?
Yes, NCT07474571 is actively recruiting participants. Contact the research team at yuhuikou@bjmu.edu.cn for enrollment information.
Where is the NCT07474571 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT07474571 clinical trial?
NCT07474571 is sponsored by Peking University People's Hospital. The trial plans to enroll 2,000 participants.