NCT07075926 Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit
| NCT ID | NCT07075926 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Kanuni Sultan Suleyman Training and Research Hospital |
| Condition | Weaning Failure of Mechanical Ventilation |
| Study Type | OBSERVATIONAL |
| Enrollment | 50 participants |
| Start Date | 2025-07-31 |
| Primary Completion | 2026-07-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 50 participants in total. It began in 2025-07-31 with a primary completion date of 2026-07-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult intensive care unit (ICU) patients. The main questions it aims to answer are: Can the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) predict successful extubation? What is the prognostic value of other echocardiographic measures such as Mitral Annular Plane Systolic Excursion (MAPSE), E/e' ratio, E/A ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) in forecasting weaning outcomes? Participants will: Be adults receiving mechanical ventilation and scheduled for weaning Undergo transthoracic echocardiography (TTE) within 2 hours after meeting weaning criteria Have the following parameters measured: LVOT VTI, MAPSE, E/e', E/A, MDT, and Tei index Be monitored for 24 hours post-extubation to determine if they remain off ventilatory support, including reintubation, non-invasive ventilation, or high-flow oxygen therapy This study aims to provide a comprehensive understanding of how systolic, diastolic, and global cardiac functions influence extubation success, potentially improving ICU decision-making and reducing complications, length of stay, and healthcare costs.
Eligibility Criteria
Inclusion Criteria: * Currently receiving mechanical ventilation in the ICU * Planned extubation after meeting standard weaning criteria * Hemodynamically stable at the time of echocardiographic evaluation * Written informed consent obtained from the patient or legally authorized representative Exclusion Criteria: * Surgery within the previous 24 hours * Presence of significant valvular heart disease or known cardiomyopathy * Inadequate acoustic window for transthoracic echocardiography * Ongoing use of extracorporeal support (e.g., ECMO) * Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours * Re-intubation planned prophylactically regardless of clinical status * Pregnant patients
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07075926 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Weaning Failure of Mechanical Ventilation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07075926 currently recruiting?
Yes, NCT07075926 is actively recruiting participants. Contact the research team at enginihsan@hotmail.com for enrollment information.
Where is the NCT07075926 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07075926 clinical trial?
NCT07075926 is sponsored by Kanuni Sultan Suleyman Training and Research Hospital. The trial plans to enroll 50 participants.