NCT07437430 Evaluation of Food Additive Contributions to Obesity: Pilot Study 1
| NCT ID | NCT07437430 |
| Status | Recruiting |
| Phase | — |
| Sponsor | McMaster University |
| Condition | Obesity (Disorder) |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2026-02-10 |
| Primary Completion | 2026-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2026-02-10 with a primary completion date of 2026-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The effects of food additives on body weight in humans are largely unknown. This is a pilot cross-over double blind RCT in obese adults aimed to test the feasibility of measuring food consumption over 24 hours after one-time administration of K sorbate versus placebo after participants reduce the background consumption of related food additives.
Eligibility Criteria
Inclusion Criteria: * Males and females age 20-80; BMI 30-39 kg/m2 inclusive; willingness and ability to follow the proposed study interventions and procedures; informed consent. Exclusion Criteria: * Weight loss of ≥3% in the last 3 months; previous or planned bariatric surgery in the next 1 year; current or planned participation in any structured weight-loss programs; current or recent (within the last 6 months) use of weight-loss-inducing drugs (including GLP-1 agonists); history of frequent intermittent or continuous use of systemic steroids; excessive alcohol consumption; recent or anticipated adjustments to mood, anxiety or anti-psychotic medications; untreated bipolar disorder or attention deficit hyperactivity disorder; eating disorder or any other disorder that may lead to significant weight changes; breastfeeding, pregnancy, planned pregnancy or planned fatherhood in the next 6 months; type 1 diabetes; uncontrolled diabetes mellitus (HbA1C≥9%); diabetes requiring treatment with insulin; aversion to foods that will be served during testing sessions.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07437430 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 80 Years, studying Obesity (Disorder). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07437430 currently recruiting?
Yes, NCT07437430 is actively recruiting participants. Contact the research team at natalia.mcinnes@mcmaster.ca for enrollment information.
Where is the NCT07437430 trial being conducted?
This trial is being conducted at Hamilton, Canada.
Who is sponsoring the NCT07437430 clinical trial?
NCT07437430 is sponsored by McMaster University. The trial plans to enroll 20 participants.
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