NCT06569264 Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation
| NCT ID | NCT06569264 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Cairo University |
| Condition | Socket Preservation |
| Study Type | INTERVENTIONAL |
| Enrollment | 26 participants |
| Start Date | 2025-11-04 |
| Primary Completion | 2026-02-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 26 participants in total. It began in 2025-11-04 with a primary completion date of 2026-02-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of the study is to evaluate radiographic ridge width change following autogenous demineralized dentin graft (ADDG) and i-PRF addition with and without vitamin C (AA) for post extraction socket preservation. The main question is: In patient with non-restorable teeth, does adding vitamin C to dentin graft and i-PRF affect the radiographic ridge width of post extraction sockets? Intervention group: Alveolar ridge preservation using vitamin C (AA) with autogenous demineralized dentin graft combined with i-PRF. Adding vitamin C to dentin graft and i-PRF might aid in reducing the dimensional changes, since it increases osteoblast proliferation and viability during socket preservation. Layers of osteoblast cell morphology can be seen at day 11 with the presence of 25mM of vitamin C. By adding vitamin C to i-PRF we can add the advantages of improving soft tissue quality as well. Control group: Alveolar ridge preservation using autogenous demineralized denting graft combined with i-PRF. Dentin particle can be used as an excellent autogenous graft material to replace other autogenous graft materials, it can be used in socket preservation. as it enhances bone formation, and has shown an ability to maintain the alveolar ridge dimensions because of its osteo-conductive properties. Moreover, dentin graft is used as a cost-effective grafting material during socket preservation. The initial therapy consists of periodontal treatment (phase I therapy) including supragingival scaling, subgingival debridement if needed, adjustment of faulty restoration and polishing. The mechanical plaque control instructions for each patient include brushing and interdental cleaning techniques. Flapless and atraumatic tooth extraction will be initiated, Then the sockets will be carefully packed with the allocated graft material that are shaped to match the individual size and contours of each socket. Once the grafts are properly adapted to the sockets, they will be covered with the corresponding graft material, and an absorbable gelatin sponge (gelfoam) will be used for socket and graft material coverage and secured using an internal crisscross knot using 5-0 monofilament polypropylene suture material.
Eligibility Criteria
Inclusion Criteria: Inclusion criteria: * ≥ 18 years of age. * Single extraction of non-molar teeth with periodontally healthy adjacent teeth. * Non-contributory medial history. * Non- restorable teeth indicated for extraction. * Requiring alveolar preservation after tooth extraction prior to placement of dental implant. * Participants that are eligible for immediate implantation, yet having factors that are hindering these patients from immediate placement of an implant at the time of extraction (ex: Financial related factors - psychological psychological factors - time related factors). * Cooperative patients who are willing to commit for 3 months follow up. Exclusion Criteria: * Pregnant female. * Acute infection at extraction site. * Systemic conditions affecting healing (e.g., diabetes, medications as bisphosphonates...) * A participant who had radiotherapy or chemotherapy. * Psychiatric patient, or with a learning disability, or unable to give consent.
Contact & Investigator
Karim fawzy, Professor
STUDY DIRECTOR
Cairo University
Frequently Asked Questions
Who can join the NCT06569264 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Socket Preservation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06569264 currently recruiting?
Yes, NCT06569264 is actively recruiting participants. Contact the research team at noha.ahmed@dentistry.cu.edu.eg for enrollment information.
Where is the NCT06569264 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT06569264 clinical trial?
NCT06569264 is sponsored by Cairo University. The principal investigator is Karim fawzy, Professor at Cairo University. The trial plans to enroll 26 participants.