NCT06754709 Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children
| NCT ID | NCT06754709 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Nantes University Hospital |
| Condition | Cardiac Surgery |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2025-02-13 |
| Primary Completion | 2034-01-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2025-02-13 with a primary completion date of 2034-01-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Cardiac surgery requires the use of extracorporeal circulation (ECC). Age-related differences in inflammatory response, the greater susceptibility of immature organ systems to injury and the larger ratio of extracorporeal circuitry to patient size make younger and smaller patients more vulnerable to organ injury. The main problem associated with ECC in neonates and infants is the duration of ECC due to heavier surgeries leading to a prolonged inflammatory state resulting in capillary leak syndrome, low cardiac output syndrome and organ dysfunction, resulting in higher morbidity and mortality. The means of limiting this inflammatory response remain limited. Future studies should aim to address new post-ECC prophylactic targets to improve myocardial and endothelial function. Cardiac metabolism is an important area of research because it plays a central role in maintaining cardiac function under stress. The study of O-GlcNAcylation could therefore be an interesting therapeutic target, given the beneficial role of its stimulation in acute stress situations, as demonstrated in sepsis.
Eligibility Criteria
Inclusion Criteria: * Age from 0 to 17 years at the time of sampling * Children undergoing CEC for cardiac surgery * Signed bio-collection consent Exclusion Criteria: * Children with an infection * Children with fever * Children with an immune deficiency * Children with autoimmune disease * Children with metabolic disease * Children with haematological diseases * Children with a genetic disease * Unsigned consent * Refusal by parents or child
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06754709 clinical trial?
This trial is open to participants of all sexes, up to 17 Years, studying Cardiac Surgery. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06754709 currently recruiting?
Yes, NCT06754709 is actively recruiting participants. Contact the research team at manon.denis-med@chu-nantes.fr for enrollment information.
Where is the NCT06754709 trial being conducted?
This trial is being conducted at Nantes, France.
Who is sponsoring the NCT06754709 clinical trial?
NCT06754709 is sponsored by Nantes University Hospital. The trial plans to enroll 300 participants.