NCT07484828 Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
| NCT ID | NCT07484828 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Laval University |
| Condition | Cardiac Arrest (CA) |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2026-06-09 |
| Primary Completion | 2027-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2026-06-09 with a primary completion date of 2027-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes. The retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives: Determine how often acid-base disorders occur in these patients and describe their characteristics. Compare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm. The investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings. This information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients. Participation does not involve any intervention, as the study uses existing medical records.
Eligibility Criteria
Inclusion Criteria: * Adult (Age \>=18 years old) * Under mechanical ventilation with endotracheal tube for : post cardiac arrest or cardiogenic shock \- Bood gases result availability up to 4 hours after coronary unit admission Exclusion Criteria: * Lack of patient anthropometric data (height and weight) available in the patient record * No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit. * Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07484828 clinical trial?
This trial is open to participants of all sexes, studying Cardiac Arrest (CA). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07484828 currently recruiting?
Yes, NCT07484828 is actively recruiting participants. Contact the research team at francois.lellouche@criucpq.ulaval.ca for enrollment information.
Where is the NCT07484828 trial being conducted?
This trial is being conducted at Québec, Canada.
Who is sponsoring the NCT07484828 clinical trial?
NCT07484828 is sponsored by Laval University. The trial plans to enroll 100 participants.