NCT06701071 Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
| NCT ID | NCT06701071 |
| Status | Recruiting |
| Phase | Phase 4 |
| Sponsor | University of Southern California |
| Condition | Infertility, Female |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2025-06-01 |
| Primary Completion | 2028-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 4 studies follow an already-approved treatment in real-world conditions to monitor long-term safety and effectiveness.
This trial targets 120 participants in total. It began in 2025-06-01 with a primary completion date of 2028-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro fertilization. The aim of the long Clomid protocol is to intensify stimulation of the ovaries and reduce both cost and injection burden for patients. Participants will be randomized to receive the long Clomid protocol vs. the typical protocol involving Clomid only for 5 days followed by growth hormone-releasing hormone (GnRH) antagonist. The primary outcome the investigators will evaluate will be the number of mature eggs retrieved.
Eligibility Criteria
Inclusion Criteria: * Undergoing IVF * Must meet POSEIDON criteria based on clinic evaluation * Female partner: Antral follicle count of 2 or more and age \<45 at time of stimulation start * Male partner/sperm source: Cannot be azoospermic * Planning freeze-all cycle (regardless of blastocyst or cleavage stage culture) or fresh transfer if randomized to short Clomid group * Planning 36-hour trigger window Exclusion Criteria: * Normal ovarian reserve or good response * Allergy or adverse reaction to Clomid * Minimal stimulation protocols * History of prior premature ovulation
Contact & Investigator
Richard Paulson
PRINCIPAL INVESTIGATOR
paulsonivf@havingbabies.com
Frequently Asked Questions
Who can join the NCT06701071 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 44 Years, studying Infertility, Female. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06701071 trial and what does that mean for participants?
Phase 4 studies are conducted after a treatment has been approved. They monitor long-term safety and real-world effectiveness in a broader patient population.
Is NCT06701071 currently recruiting?
Yes, NCT06701071 is actively recruiting participants. Contact the research team at Bonnie.Song@med.usc.edu for enrollment information.
Where is the NCT06701071 trial being conducted?
This trial is being conducted at Pasadena, United States.
Who is sponsoring the NCT06701071 clinical trial?
NCT06701071 is sponsored by University of Southern California. The principal investigator is Richard Paulson at paulsonivf@havingbabies.com. The trial plans to enroll 120 participants.