Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors
Trial Parameters
Brief Summary
This trial evaluates the effects a moderate-to-vigorous exercise intervention has on the bacterial make-up of the gastrointestinal tract (gut microbiota) in survivors of stage II-III colorectal cancer (CRC). Data shows that the gut microbiota composition and function may be drivers of CRC. High levels of exercise are associated with improved CRC prognosis and survival. While data suggests that exercise has the potential to influence gut microbiota composition and function, it is not known whether these effects contribute to improved CRC prognosis. This clinical trial evaluates the effects an exercise intervention has on gut microbiota and how these effects relate to CRC progression and patient-reported outcomes.
Eligibility Criteria
Inclusion Criteria: * 18-70 years of age * Previous diagnosis of stage II-III CRC cancer * No known current, recurrent, or metastatic disease * No comorbid or physical limitations that would limit participation at the discretion of the treating provider * At least 60 days to 3 years from last cancer-directed treatment (including surgery, chemotherapy, and radiation. Elective surgery, including ileostomy reversal, is not counted in this timing but patients must be able to eat a normal diet, without post-operative dietary limitations) * Body mass index (BMI) 18.5-30 kg/m\^2 * Able to understand and willing to sign written informed consent in English * Access to phone for study contacts * Be willing and able to attend the 24 sessions at the Fred Hutch Exercise Research Center Shared Resource * Access to internet * Willingness to participate in all study activities * Completion of all run-in activities * Participants must not be active smokers within the past 30 days. Active smoking is def