NCT03822741 Etiology and Treatment of Neonatal Seizure
| NCT ID | NCT03822741 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Children's Hospital of Fudan University |
| Condition | Seizures |
| Study Type | OBSERVATIONAL |
| Enrollment | 2,000 participants |
| Start Date | 2016-08-08 |
| Primary Completion | 2026-12-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 2,000 participants in total. It began in 2016-08-08 with a primary completion date of 2026-12-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Genetic diagnosis for neonates suffering from epilepsy has important implications for treatment, prognosis, and development of precision medicine strategies. Investigator performed exome sequencing (ES) or targeted sequencing on neonates with seizure onset within the first month of life. Investigator subgrouped our patients based on the onset age of seizure into neonatal and before 1 year (1-12 months), to compare the clinical and genetic features and treatment strategies.
Eligibility Criteria
Inclusion Criteria: * severe seizures in neonates or generalized epilepsy or intractable epilepsy in infancy with generalized tonic-clonic seizures, * seizures onset before 1 year of age, * epileptic syndromes/epileptic-encephalopathies with unknown etiology. Exclusion Criteria: * Patients were excluded if they had traumas, central nervous system infections, hypoxic-ischemic encephalopathy, vascular events, systemic infections, and diagnosed metabolic disorders, and pathogenic copy-number variants were identified using array-based comparative genomic hybridization (CGH).
Contact & Investigator
Wenhao Zhou, Doctor
✉ zwhchfu@126.comWenhao Zhou, Doctor
STUDY CHAIR
Children's Hospital of Fudan University
Frequently Asked Questions
Who can join the NCT03822741 clinical trial?
This trial is open to participants of all sexes, up to 12 Months, studying Seizures. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03822741 currently recruiting?
Yes, NCT03822741 is actively recruiting participants. Contact the research team at zwhchfu@126.com for enrollment information.
Where is the NCT03822741 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT03822741 clinical trial?
NCT03822741 is sponsored by Children's Hospital of Fudan University. The principal investigator is Wenhao Zhou, Doctor at Children's Hospital of Fudan University. The trial plans to enroll 2,000 participants.