NCT07166848 Electrostimulation Study for Ocular Graft vs. Host Disease
| NCT ID | NCT07166848 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zhonghui K. Luo, MD, PhD |
| Condition | Chronic Ocular Graft-versus-host Disease |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2025-11-30 |
| Primary Completion | 2028-11-30 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This trial is testing to see if electrostimulation treatment (ET) will be effective in treating those with ocular Graft vs. Host Disease.
Eligibility Criteria
Inclusion Criteria: * Diagnosis of chronic ocular graft vs. host disease (oGVHD) (ICCGVHD criteria probable or definite) * OSDI score of 22 or higher * NEI corneal staining score (or modified NEI score) of 2 or higher. Exclusion Criteria: * Patients with any open wound on the eyelid. * Patient with any active cornea ulcer, dacryocystitis, hordeolum, filamentary keratitis, uveitis, retinal detachment, uncontrolled glaucoma or other active pathology per PI's discretion. * Patient with a pacemaker or ICD. * Patient currently pregnant or with a potential to be pregnant during the study. * Patient undergoing any ocular surgical procedure (including intravitreal injections) within the past 3 months. * Patient undergoing any systemic surgical procedures within 2 months. * Patient undergoing any non-surgical eyelid procedure such as punctal plugs or punctal cautery within 1 month of study initiation. * Patients on cytotoxic agents, drugs that inhibit peripheral nerve regeneration (i.e. Gabapen