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Recruiting Phase 3 NCT07398846

Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.

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Trial Parameters

Condition Plaque
Sponsor Colgate Palmolive
Study Type INTERVENTIONAL
Phase Phase 3
Enrollment 135
Sex ALL
Min Age 18 Years
Max Age 70 Years
Start Date 2026-01-26
Completion 2026-04-20
Interventions
0.454%Stannous fluoride toothpaste0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe0.76% Sodium Monofluorophosphate (Na MFP) toothpaste

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Brief Summary

To evaluate the efficacy of a stannous fluoride toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.

Eligibility Criteria

Inclusion Criteria: * Signed Informed Consent Form. * Male and female subjects aged 18-70 years, inclusive. * Availability for the twelve-week duration of the clinical research study. * Good general health based on the opinion of the study investigator * Minimum of 20 permanent natural teeth (excluding third molars). * Initial gingivitis index of at least 1.0 as determined by the use of the Loe and Silness Gingival Index. * Initial mean plaque index of at least 0.6 as determined by Rustogi Modification of the Navy plaque index. Exclusion Criteria: * Presence of orthodontic appliances; * Presence of partial removable dentures; * Oral pathology, chronic disease or tumor(s) of the soft or hard tissues of the oral cavity; 4. Advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone); * Five or more carious lesions requiring immediate restorative treatment; * Use of anticonvulsants, sedatives, tranquilizers, anti-inflamm

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