Efficacy and Safety of Taitacept in Treatment of Refractory or Recurrent Anti-NMDAR/anti-LGI1 Encephalitis
Trial Parameters
Brief Summary
The main objective is to explore the efficacy and safety of Telitacicept in the treatment of refractory/recurrent anti-NMDAR and anti-LGI1 encephalitis. Through this prospective, single-center, open-label clinical trial, we aim to investigate the effectiveness and safety of Telitacicept in refractory/recurrent anti-NMDAR and anti-LGI1 encephalitis by add-on therapy of Telitacicept combined with traditional treatment.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥14 years old, male or female; 2. Symptoms of autoimmune encephalitis (AE) ≤ 9 months prior to enrollment; 3. Diagnosed as autoimmune encephalitis, diagnostic criteria as follows: 1. Rapid onset (\<3 months) of at least four of the following six major symptoms: * Abnormal (mental) behavior or cognitive dysfunction * Speech dysfunction (verbal urgency, hypospeech, mutism) * Seizures * Movement disorders, dyskinesias, or postural rigidity/abnormalities * Decreased level of consciousness * Autonomic dysfunction or central hypoventilation in the presence of one or more of the six major symptoms; 2. Positive anti-NMDAR (GluN1) IgG antibody detected in CSF or positive serum and/or cerebrospinal fluid LGI1 antibody; c．Reasonable exclusion of other etiologies and other well-defined encephalitis syndromes (e.g., Bickerstaff brainstem encephalitis, acute disseminated encephalomyelitis, Hashimoto encephalopathy, primary CNS vasculitis, Rasmussen encephalitis); 4. Refrac