NCT06410443 Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury
| NCT ID | NCT06410443 |
| Status | Recruiting |
| Phase | — |
| Sponsor | General Hospital of Shenyang Military Region |
| Condition | Radiation-Induced Intestinal Injury |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2024-08-01 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2024-08-01 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Due to the increasing number and prolonged survival of malignant tumor patients treated with radiotherapy, the complication, such as acute radiation-induced intestinal injury, has become increasingly significant. Glucocorticoids may play a therapeutic role by regulating the inflammatory response in patients with acute radiation-induced intestinal injury. However, the conclusions of related studies were controversial.
Eligibility Criteria
Inclusion Criteria: 1. Grade II-III acute radiation-induced rectosigmoid injury 2. Signed informed consents 3. Age ≥18 years 4. Rstimated survival time \>1 year Exclusion Criteria: 1. Absolute contraindications to glucocorticoids 2. A history of glucocorticoids treatment within 3 months 3. Inflammatory bowel disease or infectious intestinal disease 4. Recurrence of malignant tumor 5. Colorectal cancer or metastasis 6. Severe heart or lung diseases 7. Recent history of surgery or trauma 8. Poorly controlled hyperglycemia and hypertension 9. Active tuberculosis 10. Ssevere gastrointestinal ulcers 11. Glaucoma 12. Sychiatric diseases 13. Pregnant or lactating
Contact & Investigator
Xingshun Qi
PRINCIPAL INVESTIGATOR
The General Hospital of Northern Theater Command
Frequently Asked Questions
Who can join the NCT06410443 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Radiation-Induced Intestinal Injury. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06410443 currently recruiting?
Yes, NCT06410443 is actively recruiting participants. Contact the research team at xingshunqi@126.com for enrollment information.
Where is the NCT06410443 trial being conducted?
This trial is being conducted at Shenyang, China.
Who is sponsoring the NCT06410443 clinical trial?
NCT06410443 is sponsored by General Hospital of Shenyang Military Region. The principal investigator is Xingshun Qi at The General Hospital of Northern Theater Command. The trial plans to enroll 60 participants.