NCT07044323 Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
| NCT ID | NCT07044323 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Albert Einstein Healthcare Network |
| Condition | Phantom Pain Following Amputation of Lower Limb |
| Study Type | INTERVENTIONAL |
| Enrollment | 44 participants |
| Start Date | 2025-06-16 |
| Primary Completion | 2026-05-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 44 participants in total. It began in 2025-06-16 with a primary completion date of 2026-05-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).
Eligibility Criteria
Inclusion Criteria: * Age 18 -100 * Capacity to provide Informed Consent * Unilateral above or below knee amputation more than 3 months prior to enrollment * Absence of cognitive impairment, operationally defined as a Montreal Cognitive Assessment score of 18 or greater1. * Pain averaged over the preceding 1 month in the phantom limb rated as greater than 4 on a scale of 0-10. Exclusion Criteria: * History of significant medical or neurological disorder such as stroke or moderate to severe traumatic brain injury (operationally defined as loss of consciousness for more than 30 minutes) * History of significant or poorly controlled psychiatric disorders * Substantial depression or anxiety affecting their ability to perform tasks necessary for the study. * Current abuse of alcohol or drugs, prescription or otherwise * Nursing a child, pregnant, or intent to become pregnant during the study
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07044323 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 100 Years, studying Phantom Pain Following Amputation of Lower Limb. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07044323 currently recruiting?
Yes, NCT07044323 is actively recruiting participants. Contact the research team at Laurel.Buxbaum@jefferson.edu for enrollment information.
Where is the NCT07044323 trial being conducted?
This trial is being conducted at Philadelphia, United States, Philadelphia, United States, Seattle, United States.
Who is sponsoring the NCT07044323 clinical trial?
NCT07044323 is sponsored by Albert Einstein Healthcare Network. The trial plans to enroll 44 participants.