Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of OCD
Trial Parameters
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Brief Summary
This study aims to explore the efficacy and influencing of accelerated dTMS (deep Transcranial Magnetic Stimulation) treatment in patients with obsessive-compulsive disorder (OCD), and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).
Eligibility Criteria
Inclusion Criteria: * Aged between 18 and 50, both genders are welcome. * DSM-5 criteria for OCD. * Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study. * More than 9 years of education. * Right-handed. Exclusion Criteria: * Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder. * Severe obsessive symptoms prevent the completion of necessary assessments. * Has a history of receiving ECT therapy. * Has received rTMS or tDCS treatment within the past two months. * Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others. * Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or