NCT05553093 Effects of Tirzepatide and Insulin Glargine on Glucolipid Metabolism and Brain Function in Patients With Type 2 Diabetes
| NCT ID | NCT05553093 |
| Status | Recruiting |
| Phase | Phase 4 |
| Sponsor | Nanjing First Hospital, Nanjing Medical University |
| Condition | Type 2 Diabetes Mellitus |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2022-03-15 |
| Primary Completion | 2023-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 4 studies follow an already-approved treatment in real-world conditions to monitor long-term safety and effectiveness.
This trial targets 150 participants in total. It began in 2022-03-15 with a primary completion date of 2023-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The effects of Tirzepatide and Insulin Glargine on glucose and lipid metabolism and inflammation in patients with type 2 diabetes mellitus. Effects of Tirzepatide on the occurrence and development of cognitive impairment in diabetic patients and its associated pattern of changes in brain neural network characteristics.
Eligibility Criteria
Inclusion Criteria: * Type 2 diabetes was diagnosed according to World Health Organization(WHO) classification or other locally applicable diagnostic criteria. * Received stable metformin with or without sulfonylureas at least 2 months prior to visit 1 and between visits 1 and 3 (metformin ≥ 1000 mg/ day and does not exceed the maximum dose specified in the nationally approved guidelines;Sulfonylureas should be at least half of the maximum dose as stated in the national approved instructions). * No insulin treatment (except for gestational diabetes or short-term use in acute Settings \[duration ≤14 days\]). * At visit 1, HbA1c ≥ 7.5% and ≤ 11.0% was determined according to the central laboratory. * Body mass index (BMI) ≥ 23 kg/m2. Exclusion Criteria: * Type 1 Diabetes Mellitus (T1DM) * Had chronic or acute pancreatitis at any time prior to visit 1. * A history of proliferative diabetic retinopathy or diabetic macular degeneration or non-proliferative diabetic retinopathy requiring acute treatment. * History of severe hypoglycemia and/or insensitive hypoglycemia within 6 months prior to visit 1. * History of ketoacidosis or hyperosmolar state/coma * Have a known clinically significant gastric emptying disorder (e.g., severe diabetic gastroparesis or gastric outlet obstruction), have received or plan to undergo gastric bypass surgery or restrictive bariatric surgery (e.g., Lap-Band®) during the study period, or take long-term medications that directly affect gastrointestinal motility. * Had any of the following cardiovascular diseases in the 2 months prior to the visit: acute myocardial infarction or cerebrovascular accident (stroke) or hospitalization due to congestive heart failure (CHF). * New York Heart Association Classification of Heart Function Class III and Class IV CHF. * Have acute or chronic hepatitis, have signs or symptoms of any liver disease other than non-alcoholic fatty liver disease (NAFLD), or have alanine aminotransferase (ALT) levels \> 3.0 times the upper limit of the normal range determined by the central laboratory at visit 1;For NAFLD patients, only ALT levels ≤ 3.0 times the upper limit of the normal range (ULN) were eligible for this trial. * The estimated glomerular filtration rate (eGFR) calculated based on the Chronic Kidney Disease Epidemiology Collaboration equation（CKD-EPI）formula was less than 45 mL/min/1.73 m2, as determined by the central laboratory at visit 1. * The researchers suggest that there is evidence of significant, poorly controlled endocrine abnormalities, such as thyrotoxicosis or adrenal crisis. * Family or personal history of medullary thyroid cancer (MTC) or type 2 multiple endocrine tumor syndrome. * Serum calcitonin level ≥ 35 ng/L (pg/mL) was determined by the central laboratory at visit 1. * There was significant evidence of active autoimmune abnormalities (e.g., lupus or rheumatoid arthritis) and the investigators suggested that systemic glucocorticoid therapy might be required in the following 12 months. * Has received an organ transplant (corneal transplant allowed) or is waiting for an organ transplant. * A history of active or untreated malignancy, or a remission period of less than 5 years for a clinically significant malignancy (other than basal or squamous cell skin cancer, carcinoma in situ of the cervix, or carcinoma in situ of the prostate). * Presence of any other medical history (e.g., known drug or alcohol abuse or mental illness) that the investigator considered would have prevented the patient from complying with and completing the study protocol. * Presence of any blood disorders that may interfere with HbA1c measurements (e.g., hemolytic anemia, sickle cell disease).
Contact & Investigator
Jianhua Ma, Doctor
STUDY DIRECTOR
The First Affiliated Hospital with Nanjing Medical University
Frequently Asked Questions
Who can join the NCT05553093 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Type 2 Diabetes Mellitus. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05553093 trial and what does that mean for participants?
Phase 4 studies are conducted after a treatment has been approved. They monitor long-term safety and real-world effectiveness in a broader patient population.
Is NCT05553093 currently recruiting?
Yes, NCT05553093 is actively recruiting participants. Contact the research team at majianhua196503@126.com for enrollment information.
Where is the NCT05553093 trial being conducted?
This trial is being conducted at Nanjing, China.
Who is sponsoring the NCT05553093 clinical trial?
NCT05553093 is sponsored by Nanjing First Hospital, Nanjing Medical University. The principal investigator is Jianhua Ma, Doctor at The First Affiliated Hospital with Nanjing Medical University. The trial plans to enroll 150 participants.
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