Effects of Therapies in the Acromegaly Disease: Acral Morpho-functional Study
Trial Parameters
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Brief Summary
Acromegaly is a rare chronic disease due to excessive secretion of growth hormone (GH) and insulin-like growth factor-I (IGF-I), caused in over 98% of cases by GH-secreting pituitary adenoma. Prolonged exposure to GH/IGF-I excess is the cause of increased mortality and morbidity in these patients. Arthropathy occurs in about 75% of acromegalic patients. Any joint may be affected, with the development of osteoarthritis, arthralgia, and an increase in fracture risk. The aims of the present project are to evaluate the dimensions of hands and feet with the 3D scanner method and to perform a quantitative analysis of movement through Gait Analysis technique in de novo patients with acromegaly (group # 1) and in patients with different disease status (group #2).
Eligibility Criteria
Inclusion Criteria: * De novo patients with acromegaly (group # 1), diagnosed according to Endocrine Society guidelines, * Age equal to18 years or older * Acromegalic patients with different disease status (group #2) * Age equal to18 years or older Exclusion Criteria: * Cardiorespiratory, neurological or musculoskeletal disorder * Previous orthopaedic surgery * Previous lower limbs traumatic injuries