NCT07271147 Effects of taVNS Combined With Dexmedetomidine on POVN
| NCT ID | NCT07271147 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Affiliated Hospital of Nantong University |
| Condition | Postoperative Nausea and Vomiting |
| Study Type | INTERVENTIONAL |
| Enrollment | 176 participants |
| Start Date | 2025-11-07 |
| Primary Completion | 2026-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 176 participants in total. It began in 2025-11-07 with a primary completion date of 2026-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
To explore the effects and possible mechanisms of dexmedetomidine combined with taVNS on the incidence of postoperative nausea and vomiting in female patients undergoing laparoscopic surgery
Eligibility Criteria
Inclusion Criteria: * Women aged 18 to 65; * Elective laparoscopic surgery under general anesthesia; * Classified as American Society of Anesthesiologists (ASA) physical status I to II; * Capable of understanding the study procedures and various assessment scales and able to effectively communicate with the researchers; * Willing to participate in the study and provide written informed consent. Exclusion Criteria: * Patients with ASA anesthesia classification ≥ III; * Poorly controlled hypertension, atrioventricular block ≥ second degree, obesity (BMI \> 30 kg/m²); * Pregnant or breastfeeding; * Known allergy to drugs used in the study protocol, history of traumatic brain injury, history of gastrointestinal surgery; * Liver or kidney dysfunction (liver enzymes or creatinine ≥ 1.5 times the normal value), alcoholism or drug abuse, mental illness, use of antiemetics, opioids, psychoactive drugs, or corticosteroids within 24 hours before surgery; * Patients with implanted stimulators (such as pacemakers, implantable vagus nerve stimulators, deep brain stimulators, spinal cord stimulators, etc.), cochlear implants, or metal implants (except in dental cases); * Skin lesions or dermatological diseases at the site of electrical stimulation; * Preoperative heart rate \< 50 bpm or the presence of sinoatrial node disease or second-degree or higher atrioventricular block; * Patients unable to cooperate with assessments; * Patients participating in other clinical trials.
Contact & Investigator
Chao-Chao Zhong
PRINCIPAL INVESTIGATOR
Affiliated Hospital of Nantong University
Frequently Asked Questions
Who can join the NCT07271147 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 65 Years, studying Postoperative Nausea and Vomiting. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07271147 currently recruiting?
Yes, NCT07271147 is actively recruiting participants. Contact the research team at zhong249767626@163.com for enrollment information.
Where is the NCT07271147 trial being conducted?
This trial is being conducted at Nantong, China.
Who is sponsoring the NCT07271147 clinical trial?
NCT07271147 is sponsored by Affiliated Hospital of Nantong University. The principal investigator is Chao-Chao Zhong at Affiliated Hospital of Nantong University. The trial plans to enroll 176 participants.