NCT07601906 Effects of Progressive Restricted Blood Flow Exercises in Post Total Knee Arthroplasty
| NCT ID | NCT07601906 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Lahore University of Biological and Applied Sciences |
| Condition | Total Knee Arthroplasty Recovery |
| Study Type | INTERVENTIONAL |
| Enrollment | 48 participants |
| Start Date | 2026-05-25 |
| Primary Completion | 2026-10-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 48 participants in total. It began in 2026-05-25 with a primary completion date of 2026-10-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Total knee arthroplasty (TKA) is a commonly performed procedure for advanced knee osteoarthritis. Despite successful surgery, many patients experience postoperative impairments including pain, reduced range of motion (ROM), swelling, impaired proprioception, and kinesiophobia, which may delay functional recovery. Conventional physiotherapy is the standard rehabilitation approach following TKA; however, high-load strengthening exercises are often limited in the early postoperative phase due to pain and reduced tolerance. Blood flow restriction (BFR) exercise is an emerging rehabilitation technique that enables low-load exercise to produce strength adaptations similar to high-intensity training. While evidence supports its effectiveness for improving muscle strength, its effects on other outcomes such as pain, swelling, proprioception, and kinesiophobia are not well established. This randomized controlled trial will compare progressive BFR exercise combined with conventional physiotherapy versus conventional physiotherapy alone in patients following unilateral TKA. A total of 48 participants will be randomly allocated to two groups. The intervention will be delivered over 6 weeks with supervised sessions conducted three times per week. Outcomes will include pain, knee ROM, swelling, proprioception, kinesiophobia, and functional performance. This study aims to determine whether BFR exercise provides additional benefits in postoperative rehabilitation following TKA.
Eligibility Criteria
Inclusion Criteria: 1. Patients of age 50-65 years. 2. Primary unilateral TKA due to osteoarthritis. 3. Individuals with mild to moderate postoperative pain (NPRS score 4-7). 4. Minimum active knee flexion of 30° \& an extension lag of no more than 15°. 5. Patients should be medically stable, cognitively able to follow instructions in Urdu or english, and willing to provide written informed consent Exclusion Criteria: 1. History of deep vein thrombosis within the last six months. 2. Peripheral vascular disease and active infection. 3. Severe cardiovascular conditions 4. Neurological disorders affecting lower limb function
Contact & Investigator
Shoaib Waqas
STUDY CHAIR
Lahore University of Biological and Applied Sciences
Frequently Asked Questions
Who can join the NCT07601906 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 65 Years, studying Total Knee Arthroplasty Recovery. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07601906 currently recruiting?
Yes, NCT07601906 is actively recruiting participants. Contact the research team at Umber.nawaz@ubas.edu.pk for enrollment information.
Where is the NCT07601906 trial being conducted?
This trial is being conducted at Lahore, Pakistan.
Who is sponsoring the NCT07601906 clinical trial?
NCT07601906 is sponsored by Lahore University of Biological and Applied Sciences. The principal investigator is Shoaib Waqas at Lahore University of Biological and Applied Sciences. The trial plans to enroll 48 participants.