NCT07325812 Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography
| NCT ID | NCT07325812 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization |
| Condition | Atelectasis |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-04 |
| Primary Completion | 2026-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2026-04 with a primary completion date of 2026-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis (partial lung collapse). Atelectasis can impair intraoperative oxygenation and may increase the risk of postoperative pulmonary complications. Alveolar recruitment maneuvers (ARM) are routinely used in anesthesia practice to reopen collapsed lung regions; however, it remains unclear whether periodic application of ARM throughout surgery provides additional benefit compared with standard single-time application. This prospective, randomized controlled clinical study aims to evaluate whether periodic alveolar recruitment maneuvers applied during elective spine surgery in the prone position reduce intraoperative atelectasis and improve respiratory mechanics compared with the standard approach of performing ARM only after positioning and before extubation. Adult patients undergoing elective spine surgery under general anesthesia will be randomly assigned to either a periodic ARM group or a standard ARM group. Lung aeration will be assessed using lung ultrasound, a non-invasive and radiation-free bedside imaging method. The primary outcome is the incidence of intraoperative atelectasis assessed before extubation. Secondary outcomes include lung ultrasound aeration scores, respiratory mechanics parameters (such as airway pressures and compliance), oxygenation indices, and the occurrence of transient intraoperative respiratory or hemodynamic events. The findings of this study may help optimize intraoperative ventilation strategies in prone spine surgery and contribute to improved perioperative respiratory safety.
Eligibility Criteria
Inclusion Criteria: * Adults aged 18 to 65 years * Scheduled for elective lumbar spine surgery under general anesthesia * Surgery planned to be performed in the prone position * Expected surgical duration of at least 2 hours * American Society of Anesthesiologists (ASA) physical status I-II * Ability to provide written informed consent Exclusion Criteria: * Body mass index (BMI) greater than 30 kg/m² * History of thoracic surgery * Known or suspected chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease) * Clinically significant cardiac disease * Pregnancy or breastfeeding * Known airway anomalies Intraoperative surgical duration shorter than 2 hours Refusal or inability to provide informed consent
Contact & Investigator
Serap KARACALAR, MD (Doctor of Medicine)
PRINCIPAL INVESTIGATOR
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Frequently Asked Questions
Who can join the NCT07325812 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Atelectasis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07325812 currently recruiting?
Yes, NCT07325812 is actively recruiting participants. Contact the research team at skaracalar@yahoo.com for enrollment information.
Where is the NCT07325812 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07325812 clinical trial?
NCT07325812 is sponsored by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization. The principal investigator is Serap KARACALAR, MD (Doctor of Medicine) at Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization. The trial plans to enroll 60 participants.