NCT06296173 Open Lung Protective Extubation Following General Anesthesia
| NCT ID | NCT06296173 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Centre hospitalier de l'Université de Montréal (CHUM) |
| Condition | Intra-abdominal Surgery |
| Study Type | INTERVENTIONAL |
| Enrollment | 270 participants |
| Start Date | 2024-10-08 |
| Primary Completion | 2026-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 270 participants in total. It began in 2024-10-08 with a primary completion date of 2026-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development. Protective "open lung" mechanical ventilation aims to minimize the occurrence of atelectasis during the perioperative period. Randomized controlled studies have been performed comparing various "open lung" ventilation protocols, but these studies report varying and conflicting effects. The interpretation of these studies is complicated by the absence of imagery supporting the pulmonary impact associated with the use of different ventilation strategies. Imaging studies suggest that the gain in pulmonary gas content in "open lung" ventilation regimens disappears within minutes after the extubation. Thus, the potential benefits of open-lung ventilation appear to be lost if, at the time of extubation, no measures are used to keep the lungs well aerated. Recent expert recommendations on good mechanical ventilation practices in the operating room conclude that there is actually no quality study on extubation. Extubation is a very common practice for anesthesiologists as part of their daily clinical practice. It is therefore imperative to generate evidence on good clinical practice during anesthetic emergence in order to potentially identify an effective extubation strategy to reduce postoperative pulmonary complications.
Eligibility Criteria
Inclusion Criteria: * Adult patients (18 years of age or over) * Elective intra-abdominal surgery under general anesthesia. * Moderate or high risk of postoperative pulmonary complication according to the ARISCAT score (score of 26 or more) * Planned postoperative hospitalization Exclusion Criteria: * Expected or known difficult intubation according to the treating anesthesiologist * Postoperative mechanical ventilation (planned or unplanned) * General anesthesia performed outside the main operating room
Contact & Investigator
Martin Girard, MD
PRINCIPAL INVESTIGATOR
Centre hospitalier de l'Université de Montréal (CHUM)
Frequently Asked Questions
Who can join the NCT06296173 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Intra-abdominal Surgery. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06296173 currently recruiting?
Yes, NCT06296173 is actively recruiting participants. Contact the research team at martin.girard@umontreal.ca for enrollment information.
Where is the NCT06296173 trial being conducted?
This trial is being conducted at Ottawa, Canada, Toronto, Canada, Montreal, Canada, Québec, Canada.
Who is sponsoring the NCT06296173 clinical trial?
NCT06296173 is sponsored by Centre hospitalier de l'Université de Montréal (CHUM). The principal investigator is Martin Girard, MD at Centre hospitalier de l'Université de Montréal (CHUM). The trial plans to enroll 270 participants.