NCT07494864 Effects of Microbiological and Immunological Factors on the Lower Urinary Tract
| NCT ID | NCT07494864 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Zurich |
| Condition | Asymptomatic Bacteriuria in Subjects Not Requiring Assisted Bladder Emptying |
| Study Type | OBSERVATIONAL |
| Enrollment | 800 participants |
| Start Date | 2023-06-01 |
| Primary Completion | 2026-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 800 participants in total. It began in 2023-06-01 with a primary completion date of 2026-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Millions of patients of all ages suffer worldwide from diverse urinary pathologies, such as lower urinary tract (LUT) dysfunction, bladder pain syndrome, urinary tract infections (UTIs), or bladder cancer. The research project investigates the interplay between the bladder and the microbiome. The goal is to evaluate the association of microbiological and immunological factors with lower urinary tract health in humans.
Eligibility Criteria
General inclusion criteria: * Women and men aged ≥ 18 years old * Able to give informed consent for participation in the study * Willing to adhere to the study protocol for the whole trial period * Willing to undergo repetitive in-and-out single catheterization Specific inclusion criteria for the different study arms Arm I: Healthy controls Arm II: Asymptomatic bacteriuria in subjects not requiring assisted bladder emptying Arm III: Asymptomatic bacteriuria in subjects relying on some type of catheter for bladder emptying Arm IV: Acute non-catheter associated UTIs Arm V: Recurrent non-catheter associated UTIs Arm VI: Acute catheter-associated UTI Arm VII: Recurrent catheter-associated UTI Arm VIII: Chronic pelvic pain Arm IX: Non-neurogenic overactive bladder syndrome Arm X: Non-muscle-invasive bladder cancer Exclusion Criteria: * Current antibiotic treatment or antibiotic treatment within the last 21 days (except for study arms IV-VII) * UTI secondary to diagnosed treatable pathologies (i.e., bladder stones, enterovesical fistula etc.) and requiring specific therapy Current therapies for preventing UTIs (e.g., urine acidification, phytotherapy) or such therapies within the last 21 days (except for study arms IV-VII) * Deterioration of the upper urinary tract requiring medical intervention * Immunomodulatory therapies (apart from routine vaccination) * Congenital or acquired malformations of the LUT (study arm I only) * Immunosuppressant therapy (study arm I only) * Need for antiviral medication (study arm I only) * Significant pre-existing or current severe systemic disease such as lung, liver (exception: history of uncomplicated Hepatitis A), gastrointestinal, cardiac, immunodeficiency (including anamnestic known AIDS) or kidney disease; or active malignancy (except from bladder cancer) or any other condition as determined by history or laboratory investigation that could cause susceptibility to infections. * Presence of any unstable medical or psychiatric condition (defined by the Diagnostic and Statistical Manual of Mental Disorders, Edition 4 (DSM-IV)) that could reasonably have been expected to subject the patient to unwarranted risk from participation in the study or result in a significant deterioration of the patient's clinical course. * Drug/alcohol dependence (as defined by DSM-IV) any time during the 6 months preceding study entry. * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive human chorionic gonadotropin (hCG) laboratory test (\> 5 mIU/mL). * Suspected inability to follow the procedures of the trial (e.g., language problems, psychological disorders, dementia) such that the validity of the patient's data could be compromised. * Participation in any clinical investigation within 4 weeks prior to dosing or longer if required by local regulations, and for any other limitation of participation based on local regulations. * Patients who are unconscious, including those patients who are unconscious due to medication causing marked sedation. * History of hypersensitivity to the investigational medicinal product or to any drug with similar chemical structure.
Contact & Investigator
Thomas Kessler, Prof. Dr. med.
PRINCIPAL INVESTIGATOR
Universitätsklinik Balgrist
Frequently Asked Questions
Who can join the NCT07494864 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Asymptomatic Bacteriuria in Subjects Not Requiring Assisted Bladder Emptying. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07494864 currently recruiting?
Yes, NCT07494864 is actively recruiting participants. Contact the research team at thomas.kessler@balgrist.ch for enrollment information.
Where is the NCT07494864 trial being conducted?
This trial is being conducted at Zurich, Switzerland.
Who is sponsoring the NCT07494864 clinical trial?
NCT07494864 is sponsored by University of Zurich. The principal investigator is Thomas Kessler, Prof. Dr. med. at Universitätsklinik Balgrist. The trial plans to enroll 800 participants.