NCT07325773 Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
| NCT ID | NCT07325773 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Marmara University |
| Condition | Intraoperative Oxygenation and Pulmonary Mechanics |
| Study Type | OBSERVATIONAL |
| Enrollment | 104 participants |
| Start Date | 2025-12-01 |
| Primary Completion | 2026-07-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 104 participants in total. It began in 2025-12-01 with a primary completion date of 2026-07-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation. In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.
Eligibility Criteria
Inclusion Criteria: Adults aged 18 to 80 years Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia. ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement Exclusion Criteria: * Patients undergoing pneumonectomy * Patients with renal, hepatic, or cardiovascular failure * Patients with a BMI \< 15 kg/m² or \> 35 kg/m² * Patients with a preoperative pulmonary function test showing FEV₁ \< 1.5 liters * Patients who are transferred to the intensive care unit intubated in the postoperative period * Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
Contact & Investigator
İlayda AKARSU KAYA, Anesthesiology Resident, Principal Investigator
✉ ilaydaakarsu96@gmail.com📞 +905073306901
Meliha ORHON ERGÜN
STUDY CHAIR
Marmara University Faculty of Medicine, Department of Anesthesiology and Reanimation
Frequently Asked Questions
Who can join the NCT07325773 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Intraoperative Oxygenation and Pulmonary Mechanics. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07325773 currently recruiting?
Yes, NCT07325773 is actively recruiting participants. Contact the research team at ilaydaakarsu96@gmail.com for enrollment information.
Where is the NCT07325773 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07325773 clinical trial?
NCT07325773 is sponsored by Marmara University. The principal investigator is Meliha ORHON ERGÜN at Marmara University Faculty of Medicine, Department of Anesthesiology and Reanimation. The trial plans to enroll 104 participants.