NCT07005193 Effects of LPG and Ventilation Interventions on Reducing HAP and Improving Cardiopulmonary Health
| NCT ID | NCT07005193 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Huazhong University of Science and Technology |
| Condition | Cardiopulmonary Function |
| Study Type | INTERVENTIONAL |
| Enrollment | 1,200 participants |
| Start Date | 2025-07-01 |
| Primary Completion | 2029-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 1,200 participants in total. It began in 2025-07-01 with a primary completion date of 2029-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to evaluate the independent and synergistic effects of liquefied petroleum gas (LPG) substitution and improved ventilation on household air pollution (HAP) reduction and cardiopulmonary health. The main questions it aims to answer are: 1. Does LPG substitution or improved ventilation reduce HAP and improve cardiopulmonary health? 2. Would the combined intervention of LPG substitution and improved ventilation outperform single interventions? 3. What is the cost-effectiveness of such interventions, and are they sustainable? 4. Does the intervention reduce the incidence of cardiopulmonary clinical events? Participants will be randomized in 4 groups: A: Solid fuel + no ventilation facilities group (300 households): Continued use of solid fuels without installation of ventilation facilities and receipt of standardized health education. No LPG stoves or ventilation equipment will be provided during the intervention period. However, after the primary endpoint assessment at 12 months, all households in Group A will be provided with LPG stoves and ventilation facilities of equivalent specifications free of charge, along with health guidance. Phased cash compensation will be provided during the intervention period. B: Liquefied petroleum gas (LPG) + no ventilation facilities group (300 households): Provided with LPG stoves and instructed to use them during cooking, with regular LPG supply throughout the intervention period. Participants will also receive standardized health education. C: Solid fuel + ventilation facilities group (300 households): Continued use of solid fuels while being provided with ventilation facilities and instructed to use them during cooking. Electricity costs will be compensated during the intervention period. Participants will also receive standardized health education. D: LPG + ventilation facilities group (300 households): Provided with both LPG stoves and ventilation facilities and instructed to use both during cooking. Regular LPG supply and electricity cost compensation will be provided throughout the intervention period. Participants will also receive standardized health education.
Eligibility Criteria
1. Inclusion Criteria Primary Participants： * Aged 18-75 years; * Local permanent residents with no plans for long-term travel or relocation within one year; * Kitchen suitable for installation of ventilation facilities; * Responsible for daily household cooking, cooking ≥5 times per week; * To control for community penetration of pollution, households will be preferentially recruited in naturally ventilated, open villages, avoiding valleys or basins that hinder pollutant dispersion; preference for detached houses with ≥10 m distance from neighboring kitchens and well-sealed doors and windows. Secondary Participants: * Elderly individuals aged 65-75 living with the primary participant; * Children aged 3-6 living in the same household. 2. Exclusion Criteria: * Clinical diagnosis of major chronic diseases such as severe respiratory diseases, cardiovascular diseases, malignant tumors, or end-stage renal disease; * Pregnant or breastfeeding women; * Current smokers or individuals with self-reported exposure to productive dust or other occupational hazards; * Individuals who are unable to fully understand the study process or clearly express their own complaints, such as those with psychiatric disorders or severe neuroses, or who cannot cooperate with the study for other reasons.
Contact & Investigator
Kuai Yu
PRINCIPAL INVESTIGATOR
Huazhong University of Science and Technology
Frequently Asked Questions
Who can join the NCT07005193 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Cardiopulmonary Function. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07005193 currently recruiting?
Yes, NCT07005193 is actively recruiting participants. Contact the research team at yukuai5200@163.com for enrollment information.
Where is the NCT07005193 trial being conducted?
This trial is being conducted at Zhumadian, China, Huanggang, China, Shaoyang, China.
Who is sponsoring the NCT07005193 clinical trial?
NCT07005193 is sponsored by Huazhong University of Science and Technology. The principal investigator is Kuai Yu at Huazhong University of Science and Technology. The trial plans to enroll 1,200 participants.