Effects of Esketamine Combined With Dexmedetomidine on Postoperative Sleep Quality
Trial Parameters
Brief Summary
1. Eligible patients are randomly divided into experimental and control groups； 2. The experimental group is given esketamine combined with dexmedetomidine，while the control group is given normal saline； 3. The patients' sleep, pain, and cognition are followed up after surgery.
Eligibility Criteria
Inclusion Criteria: * Age≥ 65 years old; * Hip fracture surgery under neuraxial anesthesia; * Signed informed consent. Exclusion Criteria: * ASA classification≥ Class V; * Presence of neuraxial anesthesia contraindications: coagulation dysfunction, thrombocytopenia, neuraxial mass, puncture site infection, etc.; * Patients with contraindications to esketamine (such as allergies, intracranial aneurysms, hyperthyroidism and glaucoma); * Patients with contraindications to dexmedetomidine (allergies); * Patients with severe cardiovascular diseases such as sick sinus syndrome, severe sinus bradycardia (heart rate \< 50 beats/min), atrioventricular block grade II or above without pacemaker, unstable angina, severe valvular heart disease, severe arrhythmia, severe macrovascular disease with New York Heart Association class III patients, etc.; * Obstructive sleep apnea syndrome (STOP-BANG score \> 3 points); * Patients with severe hepatic and renal insufficiency (such as Child-Pugh score III,