NCT07550023 Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults
| NCT ID | NCT07550023 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Glasgow |
| Condition | Short Chain Fatty Acids Concentration in Stools |
| Study Type | INTERVENTIONAL |
| Enrollment | 64 participants |
| Start Date | 2026-03-23 |
| Primary Completion | 2027-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 64 participants in total. It began in 2026-03-23 with a primary completion date of 2027-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study will investigate how adding a specific type of dietary fat to daily meals for two weeks affects the gut bacteria and their activity. Participants will be randomly assigned to consume one of four types of fat: butter, coconut oil, olive oil, or sunflower oil (60 mL each day for 2 weeks). Stool and blood samples (after an overnight fast) will be collected at 3 time points during the study (Days 1, 7, and 22). These samples will be used to measure metabolites produced by gut bacteria, the types of bacteria present in the gut, blood lipids, and inflammatory markers. The study, based on previous in vitro findings, aims to understand whether different types of fats (based on their structure and level of saturation) have different effects on gut bacteria and their activity in healthy subjects.
Eligibility Criteria
Inclusion Criteria: * Adults aged 20-50 years * Body mass index (BMI) between 20 and 30 kg/m² * Generally healthy * Stable body weight (±2 kg) over the past 2 months * Living in the Glasgow area * Non-smoker Exclusion Criteria: * Use of antibiotics within the past 3 months * Current use of medications affecting gut microbiota or cardiometabolic health * Regular use of dietary supplements that may influence study outcomes (e.g. probiotics, prebiotics, vitamins, minerals, fish oil), unless willing to discontinue prior to study start * Presence of chronic gastrointestinal, metabolic, cardiovascular, hepatobiliary, or pancreatic disease * History of major gastrointestinal surgery * Diagnosed diabetes or use of lipid-lowering therapy * Known fat malabsorption disorders * Pregnant or lactating women * Post-menopausal women * Following a restrictive or specific diet (e.g. vegan, ketogenic diet) * Food allergies or intolerances relevant to study interventions (e.g. dairy, coconut) * Recent significant weight change (±2 kg in the past month) * High reliance on ready meals or takeaway foods (\>7 main meals per week) * Participation in another research study that may interfere with this study
Contact & Investigator
Athanasios Koutsos
PRINCIPAL INVESTIGATOR
University of Glasgow
Frequently Asked Questions
Who can join the NCT07550023 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 50 Years, studying Short Chain Fatty Acids Concentration in Stools. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07550023 currently recruiting?
Yes, NCT07550023 is actively recruiting participants. Contact the research team at linahalhomidan@gmail.com for enrollment information.
Where is the NCT07550023 trial being conducted?
This trial is being conducted at Glasgow, United Kingdom.
Who is sponsoring the NCT07550023 clinical trial?
NCT07550023 is sponsored by University of Glasgow. The principal investigator is Athanasios Koutsos at University of Glasgow. The trial plans to enroll 64 participants.