NCT07396233 Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis
| NCT ID | NCT07396233 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Karachi |
| Condition | Knee Osteoarthristis |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2026-02-07 |
| Primary Completion | 2027-01-19 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 150 participants in total. It began in 2026-02-07 with a primary completion date of 2027-01-19.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A randomized controlled trial will be conducted at the Department of Physiotherapy, Dr. Ziauddin Hospital and Al-Rayaz Hospital, Karachi, Pakistan. A total of 150 patients diagnosed with knee osteoarthritis, aged between 40-60 years, will be recruited through a non-probability purposive sampling technique. Written informed consent will be obtained from all eligible participants prior to enrollment. The participants will be randomly allocated by the help of computer generated randomization sheet, into two groups i.e. experimental and the control group, with 75 participants in each group. Group A (experimental group) will receive diagonal proprioceptive neuromuscular facilitation (PNF) pattern exercises, while Group B (control group) will receive conventional strength training exercises. Heat therapy will be administered to both groups. All participants will be assessed using a standardized assessment form. Outcome measures will include pain intensity, knee range of motion, functional disability, hamstring flexibility, dynamic balance, and fatigue level. A single blinded assessor will assess all participants at baseline and at post intervention. Treatment sessions will be given thrice a week on alternate days for 6 weeks.
Eligibility Criteria
Inclusion Criteria: * Both male and females with an age range between 40-60 years. * Patients diagnosed with unilateral or bilateral Knee OA. * Grade-II or grade-III on kellgren and Lawrence classification. * Patients having pain intensity more than 3.4 cm on VAS as minimum cut off value. * Duration of knee OA more than 3 months (chronic). Exclusion Criteria: * Patients with any neurological disorder. * History of lower limb arthroplasty or any other knee surgery. * Septic knee arthritis. * Inflammatory rheumatic disease such as rheumatoid arthritis and gout. * Cancer or any other malignancy such as bone tumor. * Knee deformities such as contracture, genu valgum and genu varum. * History of ligamentous injury and meniscal tear.
Contact & Investigator
Rabia Hassan, MSAPT
PRINCIPAL INVESTIGATOR
Ziauddin University
Frequently Asked Questions
Who can join the NCT07396233 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, up to 60 Years, studying Knee Osteoarthristis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07396233 currently recruiting?
Yes, NCT07396233 is actively recruiting participants. Contact the research team at rabiahassan096@gmail.com for enrollment information.
Where is the NCT07396233 trial being conducted?
This trial is being conducted at Karachi, Pakistan, Karachi, Pakistan.
Who is sponsoring the NCT07396233 clinical trial?
NCT07396233 is sponsored by University of Karachi. The principal investigator is Rabia Hassan, MSAPT at Ziauddin University. The trial plans to enroll 150 participants.