NCT05236374 Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc
| NCT ID | NCT05236374 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, Davis |
| Condition | Zinc Deficiency |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2022-10-01 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2022-10-01 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic function, leading to a greater effect on health outcomes. Specifically, whether beef, as a component of a healthy meal, will promote the absorption of zinc into cells, where the zinc will have greater effects on zinc-dependent metabolic processes supporting cardiovascular health. To maximize the observability of these beef-related effects, individuals who are 55- to 70-year-old who generally have a higher risk of zinc deficiency and cardiovascular disease will be enrolled.
Eligibility Criteria
Inclusion Criteria: * Male or postmenopausal female 55-70 years of age * Women: lack of menses for at least two years. * Subject is willing and able to comply with the study protocols. * Subject is willing to participate in all study procedures * Self-reported stable dose of prescribed medications for a minimum of 6 months * BMI 18.5 - 29.9 kg/m2 Exclusion Criteria: * Self-reported use of daily anticoagulation agents including aspirin, NSAIDs * Prescribed metaformin, statins or medications known to interfere with zinc, protein, or lipid metabolism * Vegan, Vegetarians, food faddists or those consuming a non-traditional diet (e.g. Adkins, Keto, Paleo, etc.) * Fruit consumption ≥ 3 cups/day * Regular consumption of strawberries (2-3 servings/week) * Vegetable consumption ≥ 4 cups/day * Coffee/tea ≥ 3 cups/day * Dark chocolate ≥ 3 oz/day * Alcohol intake greater than 2 drinks in a day for men, or 1 drink in a day for women. * Self-reported restriction of physical activity due to a chronic health condition * Self-reported chronic/routine high intensity exercise * Self-reported diabetes * Blood pressure ≥ 140/90 mm Hg * Self-reported renal or liver disease * Self-reported heart disease, which includes cardiovascular events and stroke * Peripheral artery disease Raynaud's syndrome or disease * Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT * Self-reported cancer within past 5 years * Self-reported malabsorption * Unwillingness to stop any supplement use six weeks prior to study initiation, including multivitamin/mineral, powders, herbal, plant or botanical, pro- and prebiotics, and oil supplements. * Smoking, vaping, cannabis use * Current enrollee in a clinical research study.
Contact & Investigator
Carl L Keen, PhD
PRINCIPAL INVESTIGATOR
Distinguished Professor Emeritus of Nutrition
Frequently Asked Questions
Who can join the NCT05236374 clinical trial?
This trial is open to participants of all sexes, aged 55 Years or older, up to 70 Years, studying Zinc Deficiency. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05236374 currently recruiting?
Yes, NCT05236374 is actively recruiting participants. Contact the research team at rrholt@ucdavis.edu for enrollment information.
Where is the NCT05236374 trial being conducted?
This trial is being conducted at Davis, United States.
Who is sponsoring the NCT05236374 clinical trial?
NCT05236374 is sponsored by University of California, Davis. The principal investigator is Carl L Keen, PhD at Distinguished Professor Emeritus of Nutrition. The trial plans to enroll 20 participants.