NCT03303586 Effects of Compression Stockings in Asthma Symptoms at Night
| NCT ID | NCT03303586 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Health Network, Toronto |
| Condition | Asthma |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2017-02-21 |
| Primary Completion | 2026-08-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2017-02-21 with a primary completion date of 2026-08-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Nocturnal worsening of asthma is common. It is characterized by overnight exacerbation of asthma symptoms such as shortness of breath, chest tightness, coughing, and wheezing, increased need of asthma medications and airway hyperresponsiveness, and decline in lung function (1). Nocturnal asthma has been attributed in part to circadian variations in lung function and airway inflammation. However, other factors including sleep, supine posture and lung volume may also contribute to nocturnal asthma. Current treatments often improve nighttime asthma symptoms. Nevertheless, nocturnal asthma is still common. Up to 2/3rd of asthma patients report nocturnal asthma symptoms, and many asthma related events occur at night, indicating poor asthma control. Results from an ongoing study suggest that in asthma while subjects were supine, fluid shifted out of the legs and accumulated in the thorax (rostral fluid shift) contributing to lower airway narrowing in asthma. A previou study has shown that wearing compression stockings during the day reduces fluid retention in the legs, reduces nocturnal rostral fluid shift out of the legs, and improves sleep apnea (2, 3). The aims of the proposed study is investigate whether off-the-shelf, below the knee compression stockings will attenuate nocturnal fluid shift and lower airway narrowing in asthma.
Eligibility Criteria
Inclusion Criteria: non-smokers or former smokers (\<10 pack/year) Exclusion Criteria: uncontrolled hypertension
Contact & Investigator
Azadeh Yadollahi
PRINCIPAL INVESTIGATOR
Scientist
Frequently Asked Questions
Who can join the NCT03303586 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 75 Years, studying Asthma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03303586 currently recruiting?
Yes, NCT03303586 is actively recruiting participants. Contact the research team at cristina.francisco@uhn.ca for enrollment information.
Where is the NCT03303586 trial being conducted?
This trial is being conducted at Toronto, Canada.
Who is sponsoring the NCT03303586 clinical trial?
NCT03303586 is sponsored by University Health Network, Toronto. The principal investigator is Azadeh Yadollahi at Scientist. The trial plans to enroll 40 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.