NCT07085754 Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
| NCT ID | NCT07085754 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Yuhui Qiu |
| Condition | Sleep |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-08-08 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-08-08 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.
Eligibility Criteria
Inclusion Criteria: * Age 18-40 years, gender not limited * Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications * Cognitively normal (Mini-Mental State Examination (MMSE) score \> 28) * Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points) * Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study Exclusion Criteria: * Presence of day-night sleep reversal * Shift work within the past 6 months * Travel across time zones or experience of jet lag within the past three weeks * Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL \[or 8 g\] of pure alcohol) * Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation * Family history of early-onset dementia * Self-Rating Depression Scale (SDS) score ≥ 53, Self-Rating Anxiety Scale (SAS) score ≥ 50 * Female participants who are currently pregnant or breastfeeding * Individuals who need to drive or operate vehicles or machinery during the study period
Frequently Asked Questions
Who can join the NCT07085754 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 40 Years, studying Sleep. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07085754 currently recruiting?
Yes, NCT07085754 is actively recruiting participants. Visit ClinicalTrials.gov or contact Yuhui Qiu to inquire about joining.
Where is the NCT07085754 trial being conducted?
This trial is being conducted at Guangzhou, China.
Who is sponsoring the NCT07085754 clinical trial?
NCT07085754 is sponsored by Yuhui Qiu. The trial plans to enroll 60 participants.