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Recruiting NCT06612372

NCT06612372 Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint

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Clinical Trial Summary
NCT ID NCT06612372
Status Recruiting
Phase —
Sponsor Peking University Third Hospital
Condition Cartilage Degeneration
Study Type INTERVENTIONAL
Enrollment 26 participants
Start Date 2023-09-10
Primary Completion 2024-11-10

Trial Parameters

Condition Cartilage Degeneration
Sponsor Peking University Third Hospital
Study Type INTERVENTIONAL
Phase N/A
Enrollment 26
Sex MALE
Min Age 25 Years
Max Age 50 Years
Start Date 2023-09-10
Completion 2024-11-10
Interventions
60-day-6° head-down bed rest

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Brief Summary

Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.

Eligibility Criteria

Inclusion Criteria: * (1) male; (2) age 25-50 years old; (3) height between 160-175 cm, weight ≥50kg, and BMI between 18.5-26 kg/m²; (4) good general health status. Exclusion Criteria: * (1) history of alcoholism; (2) smoking ≥5 cigarettes/day in the 3 months before the test; (3) drug dependence or use of medications affecting bone metabolism within 2 weeks before screening; (4) presence of metal implants, severe vertigo, or severe snoring.

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