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Recruiting NCT06930235
Effectiveness of Midodrine as an Adjuvant to Norepinephrine in Weaning Critically Ill Patients From Vasopressors
Trial Parameters
Condition Shock
Sponsor Sohag University
Study Type INTERVENTIONAL
Phase N/A
Enrollment 112
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2025-03-13
Completion 2025-10-13
Interventions
Weaning critically ill patients from norepinephrine using midodrine as an adjuvant to norepinephrineWeaning critically ill patients from norepinephrine without use of midodrine as an adjuvant
Brief Summary
This study aims to evaluate the effectiveness of midodrine as an adjuvant to norepinephrine in weaning critically ill patients from vasopressors
Eligibility Criteria
Inclusion Criteria: * Patients with refractory hypotension on an intravenous vasopressor for more than 24 h but deemed clinically stable. * Patients on noradrenaline support \<10 μg/min Exclusion Criteria: * Known allergy to midodrine. * Severe shock state, as evidenced by multiple vasopressor infusions or high vasopressor requirement (i.e. noradrenaline \>10 μg/min) * Patients with severe organic heart disease (e.g., heart failure, sever aortic stenosis), pregnancy, thyrotoxicosis or pheochromocytoma. * Those with no enteral route available.
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