NCT07605182 Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age
| NCT ID | NCT07605182 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Vietnam Military Medical University |
| Condition | Male Infertility |
| Study Type | INTERVENTIONAL |
| Enrollment | 378 participants |
| Start Date | 2026-07-15 |
| Primary Completion | 2027-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 378 participants in total. It began in 2026-07-15 with a primary completion date of 2027-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Male infertility contributes significantly to infertility, particularly in advanced paternal age men where sperm DNA fragmentation is increased. Conventional density gradient centrifugation may induce oxidative stress and sperm damage. LensHooke® CA0 is a centrifugation-free sperm sorting device designed to improve sperm quality and reduce DNA fragmentation. This prospective comparative study evaluates the effectiveness of CA0 versus conventional density gradient centrifugation on post-processing sperm quality, DNA fragmentation index, blastocyst formation, euploid embryo rate, and clinical pregnancy outcomes in IVF/ICSI cycles involving men aged 40 years or older
Eligibility Criteria
Inclusion Criteria: * Male partners aged ≥ 40 years * Semen analysis: volume ≥ 1.4 mL, sperm concentration ≥ 6 million/mL, progressive motility (PR) ≥ 20% after 3-5 days of abstinence. * Female partners with ≥ 5 mature (MII) oocytes retrieved. * Couples undergoing ICSI with PGT-A and elective single embryo transfer (eSET). * Willingness to participate and sign informed consent. Exclusion Criteria: * Azoospermia, surgical sperm retrieval, or use of cryopreserved sperm. * Female uterine or ovarian conditions severely affecting IVF outcomes. * Use of donor sperm or donor oocytes
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07605182 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, studying Male Infertility. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07605182 currently recruiting?
Yes, NCT07605182 is actively recruiting participants. Contact the research team at trinhtheson@vmmu.edu.vn for enrollment information.
Where is the NCT07605182 trial being conducted?
This trial is being conducted at Hà Nội, Vietnam.
Who is sponsoring the NCT07605182 clinical trial?
NCT07605182 is sponsored by Vietnam Military Medical University. The trial plans to enroll 378 participants.