Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
Trial Parameters
Brief Summary
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in preventing ASCVD among older people living with HIV (PLWH).
Eligibility Criteria
Inclusion Criteria: 1. HIV-infected patients diagnosed according to the diagnostic criteria of China AIDS diagnosis and treatment guidelines; 2. Aged 40 years and above; 3. at risk of CVD: having any two of those risk factors: dyslipidemia, DM or elevated blood glucose, smoking, hypertention or elevated blood pressure, metabolic syndrome,overweight/obesity; or PCE score\>5%, 4. Those with a predicted survival time of \>1 year; 5. No plans to leave the depth in the next 3 months; 6. Voluntary participation in this study and signing the informed consent Exclusion Criteria: 1. Those with a previous history of CVD; 2. Those with HIV-related neurocognitive impairment, Alzheimer's disease or dementia, and a variety of serious opportunistic infections; 3. Currently suffering from malignant tumors, gastrointestinal diseases; People with an aversion to eating; 4. Allergic to nuts and fish; 5. People who take medicinal calcium \>1000 mg per day or omega-3 supplements; 6. Plan to become pregnant