Effectiveness of Endoscopic Sleeve Gastroplasty in Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Trial Parameters
Brief Summary
Endoscopic weight loss procedures, also termed endoscopic sleeve gastroplasty (ESG), has been proposed as a non-surgical procedure for managing obesity and offers a standard weight loss approach. Realizing there is a knowledge gap in applying ESG to morbidly obese patients with NAFLD, the investigators propose studying the efficacy of weight control and functional outcomes of ESG. This prospective pilot study is aimed to study the safety profiles, quality of life, and changes and improvements in the anthropometric, metabolic, and biochemical changes in these patients.
Eligibility Criteria
Inclusion Criteria: * Body mass index (BMI) greater than 30 kg/m2, who are eligible for ESG * Patients scheduled to undergo an endoscopic bariatric weight loss procedure (ESG) * Patients older than 18 years and younger than 75 years of age at the time of consent * Patients able to provide written informed consent on the Institutional review board (IRB) approved informed consent form * Patients willing and able to comply with study requirements for follow-up Exclusion criteria: * Patients who are treated with intragastric balloons * Family history of esophageal, gastric, or duodenal malignancy and active gastric ulceration, * Pre-existing esophageal stenosis/stricture preventing the advancement of an endoscope during screening/baseline Esophagogastroduodenoscopy (EGD) * Presence of any gastric condition which required endoscopic surveillance (e.g., known gastric intestinal metaplasia), * Known vascular abnormalities, obligate therapeutic anticoagulation, and pregnancy/lactation * Eviden