Effect of Stem Cell Infusion Time on aGVHD in Patients With Hematological Malignancies Post UCBT
Trial Parameters
Brief Summary
To observe the effect of stem cell infusion on the development of acute graft- versus-host disease (aGVHD) in patients with malignant hematologic diseases after single-unit unrelated cord blood transplantation (sUCBT).
Eligibility Criteria
Inclusion Criteria: * Definite diagnosis of malignant hematologic disease before transplantation, age, gender and race are not limited; * Participants were required to have achieved complete remission with negative minimal residual disease (MRD) prior to transplantation; * Participants who are proposed to receive sUCBT for the first time; * Eastern Cooperative Oncology Group (ECOG) score 0-2; * No serious organ failure and active infection; * Voluntary open randomized controlled study to observe whether the time of stem cell infusion affects the occurrence of aGVHD after transplantation; * Each subject must sign an informed consent form (ICF) indicating that he/ she understands the purpose and procedures of the study and is willing to participate in the study; in view of the subject's condition, if the participant's own signature is not conducive to the treatment of his/her condition, the ICF will be signed by the legal representative. Exclusion Criteria: * Those with severe organ dysf