NCT06216665 Effect of Pulsatile Hormone Administration on Insulin Action
| NCT ID | NCT06216665 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Pennington Biomedical Research Center |
| Condition | Insulin Sensitivity |
| Study Type | INTERVENTIONAL |
| Enrollment | 12 participants |
| Start Date | 2024-03-04 |
| Primary Completion | 2025-12 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
In humans, insulin is secreted in pulses from the pancreatic beta-cells, and these oscillations help to maintain fasting plasma glucose levels within a narrow normal range. Given the fluctuations in insulin concentrations, oscillations enhance precision of control. The hyperinsulinemic euglycemic clamp test (clamp) involves a continuous infusion of insulin and is the gold standard for measuring insulin sensitivity. In this study, insulin sensitivity measured using the standard clamp will be compared with a clamp in which the same total amount of insulin as the standard clamp is infused every five minutes instead of continuously.
Eligibility Criteria
Inclusion Criteria: * Completion of the Motivate Study (NCT05649176) Exclusion Criteria: * Non-completion of the end-of-study hyperinsulinemic euglycemic clamp test of the Motivate study