NCT06648954 Effect of Multisite High-definition Transcranial Direct Current Stimulation Targeting Sensorimotor Network
| NCT ID | NCT06648954 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Chinese University of Hong Kong |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2022-08-13 |
| Primary Completion | 2024-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 30 participants in total. It began in 2022-08-13 with a primary completion date of 2024-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Transcranial direct current stimulation (tDCS) has been applied to facilitate cortical excitability in stroke populations, as increasing evidence suggests that clinical recovery from stroke is attributed to neuroplastic reorganization. However, recovery from stroke following this kind of non-invasive neuromodulation remains divergent across stroke patients due to variations in their etiologies, lesion profiles and post-stroke duration. A novel multisite high definition tDCS (HD-tDCS) in healthy people showed that such network-targeted stimulation could enhance motor excitability beyond conventional stimulation which targeting only one region. The electrode placements could be determined by the montage optimization, which targets individual motor network activation navigated by task-based fMRI using computation algorithms. By targeting motor network, the new multisite electrode montage may provide a potential to facilitate better cortical activation than conventional tDCS montage.
Eligibility Criteria
Inclusion Criteria: 1. first-ever stroke, the duration after stroke exceeds 12 months; 2. mild to moderate upper extremity motor function deficit, determined by the Fugl-meyer assessment of upper extremity (FMAUE) scores between 15 and 53; 3. could voluntarily perform grasping hand movement. 4. sufficient cognitive function to follow the assessment and experiment instructions. Exclusion Criteria: 1. history of epilepsy, or any other contradictions of brain stimulation and MRI scanning; 2. severe joint contracture of elbow or shoulder, or pain induced by any other neurological, neuromuscular, and orthopedic diseases.
Contact & Investigator
Raymond Kai-yu Tong, PhD
PRINCIPAL INVESTIGATOR
Department of Biomedical Engineering, CUHK
Frequently Asked Questions
Who can join the NCT06648954 clinical trial?
This trial is open to participants of all sexes, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06648954 currently recruiting?
Yes, NCT06648954 is actively recruiting participants. Contact the research team at kytong@cuhk.edu.hk for enrollment information.
Where is the NCT06648954 trial being conducted?
This trial is being conducted at Hong Kong, Hong Kong.
Who is sponsoring the NCT06648954 clinical trial?
NCT06648954 is sponsored by Chinese University of Hong Kong. The principal investigator is Raymond Kai-yu Tong, PhD at Department of Biomedical Engineering, CUHK. The trial plans to enroll 30 participants.
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